https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The nerve-cancer connection in ovarian cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31996 Wed 22 Mar 2023 16:06:43 AEDT ]]> PRONGF/NGF and nerve infiltration in prostate and breast cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22043 Wed 11 Apr 2018 10:12:18 AEST ]]> The neurotrophic tyrosine kinase receptor 1 (TrkA) is overexpressed in oesophageal squamous cell carcinoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46031 NTR), are increasingly implicated in cancer progression, but their clinicopathological significance in oesophageal cancer is unclear. In this study, the expression of NGF, NTRK1 and NGFR were analysed by immunohistochemistry in a cohort of 303 oesophageal cancers versus 137 normal adjacent oesophageal tissues. Immunostaining was digitally quantified and compared to clinicopathological parameters. NGF and NGFR staining were found in epithelial cells and at similar levels between oesophageal cancers and normal oesophageal tissue. NGFR staining was slightly increased with grade (p=0.0389). Interestingly, NTRK1 staining was markedly higher in oesophageal squamous cell carcinoma (OR 2.31, 95%CI 1.13–4.38, p<0.0001) and significantly lower in adenocarcinoma (OR 0.50, 95%CI 0.44–0.63, p<0.0001) compared to normal oesophageal tissue. In addition, NTRK1 staining was decreased in grade 2 and grade 3 (OR 0.51, 95%CI 0.21–1.40, p<0.0001) compared to grade 1, suggesting a preferential involvement of this receptor in the more differentiated forms of oesophageal carcinomas. Together, these data point to NTRK1 as a biomarker and a candidate therapeutic target in oesophageal squamous cell carcinoma.]]> Wed 09 Nov 2022 15:59:02 AEDT ]]> Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41003 Thu 21 Jul 2022 10:51:13 AEST ]]> NGF and ProNGF: regulation of neuronal and neoplastic responses through receptor signaling https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27076 Sat 24 Mar 2018 07:40:44 AEDT ]]> ProNGF, NGF and their receptors in tumour innervation and progression: a study in breast and thyroid cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31979 Mon 23 Sep 2019 11:59:37 AEST ]]> Expression of NGF/proNGF and Their Receptors TrkA, p75<sup>NTR</sup> and Sortilin in Melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51398 Mon 04 Sep 2023 14:57:50 AEST ]]>